WECF Deutschland

WECF France

WECF Nederland

Facebook

Twitter

YouTube

Paraben esters: review of recent studies of endocrine toxicity

Review of recent studies of endocrine toxicity, absorption, esterase and human exposure, and discussion of potential human health risks.

14.11.2011 |Journal of Applied Toxicology




This toxicology update reviews research over the past four years since publication in 2004 of the first measurement of intact esters of p-hydroxybenzoic acid (parabens) in human breast cancer tissues, and the suggestion that their presence in the human body might originate from topical application of bodycare cosmetics.

The presence of intact paraben esters in human body tissues has now been confirmed by independent measurements in human urine, and the ability of parabens to penetrate human skin intact without breakdown by esterases and to be absorbed systemically has been demonstrated through studies not only in vitro but also in vivo using healthy human subjects.

Using a wide variety of assay systems in vitro and in vivo, the oestrogen agonist properties of parabens together with their common metabolite (p-hydroxybenzoic acid) have been extensively documented, and, in addition, the parabens have now also been shown to possess androgen antagonist activity, to act as inhibitors of sulfotransferase enzymes and to possess genotoxic activity.

With the continued use of parabens in the majority of bodycare cosmetics, there is a need to carry out detailed evaluation of the potential for parabens, together with other oestrogenic and genotoxic co-formulants of bodycare cosmetics, to increase female breast cancer incidence, to interfere with male reproductive functions and to influence development of malignant melanoma which has also recently been shown to be influenced by oestrogenic stimulation.

More detailed information about the review can be found here.

To learn more about endocrine disrupting chemicals and their regulation in the EU, please read SIN List 2.0 targets endocrine disrupting chemicals for priority action in the EU.

Related News

Worries about consequences for children of pesticides present in water
Far too many residues of pesticides are present in the waters of Drenthe (Dutch province). This needs to be reduced. But how?
19.02.2018

A Plastic Free Lent
Join us on our challenge for this Lent: reduce your plastics consumption for 40 days!
13.02.2018

First edition of WECF’s “DESIGN-MOI UN JOUET” (Design me a toy) contest
Two teams of students were awarded for their creative designs of healthy toys
16.01.2018

Gender, Chemicals and Waste high level event in Abuja, Nigeria
Women Environment Programme (WEP) Nigeria, and WECF organise high-level meeting in Abuja, Nigeria on Gender, Chemicals and Waste, on 10-12 of January 2018
10.01.2018

Women's exposure to toxic chemicals
Women’s bodies are ready to produce a new life and milk, hence it’s easier to accumulate toxic chemicals in their higher levels of fatty tissue.
20.12.2017